PRS3459
抗 半胱天冬酶-1 (ab1) 兔抗
affinity isolated antibody, buffered aqueous solution
别名:
抗 ICE, 抗 IL-1β; 转化酶, 抗 Caspase 1，凋亡相关半胱氨酸肽酶（白介素 1，β，转化酶）
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunofluorescence
immunohistochemistry
indirect ELISA
western blot
immunohistochemistry
indirect ELISA
western blot
Species reactivity:
human
Citations:
10
Technique(s):
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗 半胱天冬酶-1 (ab1) 兔抗, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CASP1(834)
Application
家兔抗半胱天冬酶1 (ab1) 抗体可用于蛋白质印迹和免疫荧光。
Biochem/physiol Actions
Caspase-1可以将j促炎细胞因子白细胞介素-1β （IL-1β）和 IL-18转化为活性形式。 它参与细胞焦亡（pyroptosis）。它在冠状动脉粥样硬化患者的主动脉中过度表达。它通过诱导膜的生物发生来修复成孔毒素造成的损伤，从而有助于宿主细胞存活。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
半胱天冬酶-1也被称为白介素-1β转化酶(ICE)。它位于染色体11q22.2上。它有10个外显子、一个N端CARD（半胱天冬酶激活和募集结构域）、一个大P20亚基和一个小P10亚基。它存在于白细胞、单核细胞和上皮细胞中。
Immunogen
由人Caspase-1羧基末端附近的16个氨基酸组成的肽。
Other Notes
可以使用阻断肽 SBP3459阻断该抗体的作用。
Physical form
溶剂为含有0.02%叠氮化钠的磷酸盐缓冲盐水
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1
Shamaa OR, et al.
PLoS ONE, 10(11) (2015)
CASP1 (caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase))
Kumar Y, et al.
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2007)
Pyroptosis, a novel mechanism implicated in cataracts
Jin X, et al.
Molecular Medicine Reports, 18(2), 2277-2285 (2018)
Guibin Xu et al.
Aging, 8(5), 977-985 (2016-05-30)
Excessive deposition of extracellular matrix proteins in renal tissues causes renal fibrosis and renal function failure. Mammalian cells primarily use the autophagy-lysosome system to degrade misfolded/aggregated proteins and dysfunctional organelles. MAP1S is an autophagy activator and promotes the biogenesis and
Qi Chen et al.
The Journal of biological chemistry, 290(43), 26051-26058 (2015-09-13)
Autophagy is a cellular process that controls and executes the turnover of dysfunctional organelles and misfolded or abnormally aggregated proteins. Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) activates the initiation of autophagy. Autophagosomes migrate along acetylated microtubules to
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