SMC^® Human TDP-43 Immunoassay Kit

SMC is a registered trademark of Singulex

SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany

used for ultrasensitive quantification of Human TDP-43 in human serum, plasma, and CSF.

Alzheimer′s Disease / Aging / Nervous System / Neurodegenerative Diseases / Neurofilament & Neuron Metabolism / Neuronal & Glial Markers / Neurodegenerative Medicine / Neuroscience

This assay was tested for cross-reactivity with phospho-α-synuclein (S129) and phospho-Tau (T181). No cross-reactivity was detected with these analytes.

Although TDP-43 was detectable in non-human primate (rhesus macaque and cynomolgus monkey), feline, and canine samples, the assay has not been verified for these species.

• Sensitivity: LLOQ 5,210 fg/mL* (SMCxPRO^® Instrument)
• Standard Curve Range: 2,600-6,000,000 fg/mL
• Intra-assay CV: <15%
• Inter-assay CV: <20%
• Linearity: Serum: 105% Plasma 103% CSF: 103%
• Recovery: Serum: 96% Plasma: 100% CSF: 89%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

NeuroscienceNeurological DisordersNeurodegenerative Diseases

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

TAR DNA-binding protein 43 (TDP-43) plays a crucial role in regulating gene expression, RNA processing, and the transport of RNA within neurons. It is involved in maintaining neuronal health by facilitating the splicing of pre-mRNA and ensuring the stability of mRNA, which is essential for proper protein synthesis. When TDP-43 mislocalizes from the nucleus to the cytoplasm, it forms toxic aggregates that disrupt cellular function and contribute to neuronal degeneration. TDP-43 has become associated with conditions such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) as its abnormal accumulation often correlates with disease severity and progression. Investigation into the role of TDP-43 in neuroinflammation and neurodegeneration can help identify potential therapeutic targets that counteract its harmful effects on neuronal health and function in various neurodegenerative disorders.

96 well assay