SMC^® Human Total Tau High Sensitivity Immunoassay Kit

SMC is a registered trademark of Singulex

SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany

• Sensitivity: LLOQ 4,690 fg/mL* (SMCxPRO^® Instrument)
• Standard Curve Range: 1170-1,200,000 fg/mL
• Intra-assay CV: <15%
• Inter-assay CV: <20%
• Linearity: Serum: 107% Plasma: 115% CSF: 103%
• Recovery: Serum 70% Plasma: 82% CSF: 91%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

NeuroscienceNeurological DisordersNeurodegenerative DiseasesAlzheimer′s Disease

Alzheimer′s Disease / Aging / Nervous System / Neurodegenerative Diseases / Neurofilament & Neuron Metabolism / Neuronal & Glial Markers / Neurodegenerative Medicine / Neuroscience

Although Total Tau was detectable in non-human primate (rhesus macaque and cynomolgus monkey), feline, rat, mouse, and canine samples, the assay has not been verified for these species.

Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Tau is a microtubule-associated protein predominantly found in neurons, where it stabilizes microtubules and supports axonal structure and function. By promoting microtubule assembly, tau facilitates intracellular transport and ensures effective communication between neurons. In neurological disorders, particularly neurodegenerative diseases such as Alzheimer′s disease, tau undergoes hyperphosphorylation, leading to its misfolding and aggregation into neurofibrillary tangles. These tangles disrupt microtubule stability, impair neuronal function, and contribute to cell death and cognitive decline.

Elevated tau levels in cerebrospinal fluid (CSF) often indicate ongoing neurodegeneration. Tau also plays a role in neuroinflammation; its presence can activate glial cells, which exacerbate inflammatory responses and promote further neuronal injury. Overall, tau is crucial for maintaining neuronal health, and its dysregulation is central to the pathogenesis of various neurodegenerative disorders.

96 well assay