SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
别名:
FBL1, FBXL1, FLB1, p45
物种:
Human SKP2 (6502), Mouse Skp2 (27401), Rat Skp2 (294790), domestic cat SKP2 (101099275), dog SKP2 (489228), fruit fly Skp2 (40548), domestic guinea pig Skp2 (100720705), naked mole-rat Skp2 (101706248), Horse SKP2 (100053697), cow SKP2 (519018) ...展开
UniProtKB ID:
基因ID:
- Human(6502) Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]
- Mouse(27401) S-phase kinase-associated protein 2 (p45)
- Rat(294790) S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
- domestic cat(101099275) S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
- dog(489228) S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
- fruit fly(40548) CG9772 gene product from transcript CG9772-RA
- domestic guinea pig(100720705) S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
- naked mole-rat(101706248) S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
- Horse(100053697) S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
- cow(519018) S-phase kinase-associated protein 2 (p45)
- sheep(101109483) S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
- Zebrafish(563708) S-phase kinase-associated protein 2 (p45)
- chicken(427437) S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
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Antibodies
货号
说明
物种反应性
应用
Anti-SKP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
Anti-Skp2 Antibody, clone 1B13 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
bovine, human, monkey, mouse, porcine
应用
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-SKP2 antibody produced in rabbit, ,
物种反应性
human, mouse, rat
应用
immunohistochemistry
western blot
western blot
Anti-SKP2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
proximity ligation assay
western blot
western blot
Anti-SKP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence
western blot
western blot
Proteins
货号
说明
物种
SCF-Skp2 Protein Complex, Active, 10 µg, Active complex of five (5) full length, recombinant human enzymes: Skp1, Skp2, Cul1, Rbx1 & Cks1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.,
物种
human