跳转至内容
Merck
CN
  • Nanomaterials-Mediated Co-Stimulation of Toll-Like Receptors and CD40 for Antitumor Immunity.

Nanomaterials-Mediated Co-Stimulation of Toll-Like Receptors and CD40 for Antitumor Immunity.

Advanced materials (Deerfield Beach, Fla.) (2022-09-20)
Jingyue Yan, Yuebao Zhang, Shi Du, Xucheng Hou, Wenqing Li, Chunxi Zeng, Chengxiang Zhang, Jeffrey Cheng, Binbin Deng, David W McComb, Weiyu Zhao, Yonger Xue, Diana D Kang, Xiaolin Cheng, Yizhou Dong
摘要

Toll-like receptors (TLRs) and CD40-related signaling pathways represent critical bridges between innate and adaptive immune responses. Here, an immunotherapy regimen that enables co-stimulation of TLR7/8- and CD40-mediated pathways is developed. TLR7/8 agonist resiquimod (R848) derived amino lipids, RAL1 and RAL2, are synthesized and formulated into RAL-derived lipid nanoparticles (RAL-LNPs). The RAL2-LNPs show efficient CD40 mRNA delivery to DCs both in vitro (90.8 ± 2.7%) and in vivo (61.3 ± 16.4%). When combined with agonistic anti-CD40 antibody, this approach can produce effective antitumor activities in mouse melanoma tumor models, thereby suppressing tumor growth, prolonging mouse survival, and establishing antitumor memory immunity. Overall, RAL2-LNPs provide a novel platform toward cancer immunotherapy by integrating innate and adaptive immunity.

材料
货号
品牌
产品描述

Sigma-Aldrich
Granulocyte-Macrophage Colony-Stimulating Factor Protein, Recombinant mouse, The Granulocyte Macrophage Colony Stimulating Factor protein (GM-CSF protein) is a potent species specific stimulator of bone marrow cells.
登录查看公司和协议定价