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Merck
CN

P7778

Sigma-Aldrich

磷脂酶 A2 来源于莫桑比克射毒眼镜蛇

lyophilized powder, ~1,500 units/mg protein

别名:

Lecithinase A, PLA2, Phosphatidylcholine 2-acylhydrolase

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About This Item

CAS号:
EC 号:
MDL编号:
UNSPSC代码:
12352204

形式

lyophilized powder

比活

~1,500 units/mg protein

组成

Protein, ~90%

pI 

8.8 (isoenzyme)

储存温度

−20°C

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生化/生理作用

Hydrolyzes the β-ester bond of zwitterionic glycerophospholipids. Preferred substrates are phosphatidylcholine, phosphatidylethanolamine, and their plasmalogen analogues. Phosphatidylinositol and phosphatidylserine are also hydrolyzed. Aggressively attacks phospholipids in membranes of intact cells.

其他说明

The toxic phospholipase A2 from Naja mossambica mossambica.

单位定义

One unit will hydrolyze 1.0 μmole of soybean L-α-phosphatidylcholine to L-α-lysophosphatidylcholine and a fatty acid per min at pH 8.9 at 25 °C.

分析说明

Protein determined by biuret.

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

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Chie Aoki-Utsubo et al.
Bio-protocol, 8(10), e2855-e2855 (2018-05-20)
In a narrow definition, virucidal activity represents the activity by which to interact with and physically disrupt viral particles. In a broad definition, it includes the activity by which to functionally inhibit (neutralize) viral infectivity without apparent morphological alterations of
Florian Bleffert et al.
eLife, 11 (2022-05-11)
Cells steadily adapt their membrane glycerophospholipid (GPL) composition to changing environmental and developmental conditions. While the regulation of membrane homeostasis via GPL synthesis in bacteria has been studied in detail, the mechanisms underlying the controlled degradation of endogenous GPLs remain
Ming Chen et al.
Scientific reports, 7(1), 15931-15931 (2017-11-23)
Hepatitis C virus (HCV), dengue virus (DENV) and Japanese encephalitis virus (JEV) belong to the family Flaviviridae. Their viral particles have the envelope composed of viral proteins and a lipid bilayer acquired from budding through the endoplasmic reticulum (ER). The
Willem van de Veen et al.
The Journal of allergy and clinical immunology, 131(4), 1204-1212 (2013-03-05)
IL-10-producing regulatory B cells suppress immune responses, and lack of these cells leads to exacerbated symptoms in mouse models of chronic inflammation, transplantation, and chronic infection. IgG4 is a blocking antibody isotype with anti-inflammatory potential that is induced in human
J J Seilhamer et al.
The Journal of biological chemistry, 264(10), 5335-5338 (1989-04-05)
Synovial fluid from arthritic patients contains multiple forms of phospholipase A2 (PLA2), as resolved by high performance liquid chromatography (Seilhamer, J.J., Plant, S., Pruzanski, W., Schilling, J., Stefanski, E., Vadas, P., and Johnson, L. K. (1989) J. Biochem. (Tokyo), submitted

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