质量水平
检测方案
≥95% (HPLC)
形式
buffered aqueous solution
浓度
0.1 mg/mL in 0.1 M sodium acetate pH 5.0
抗生素抗菌谱
Gram-positive bacteria
作用机制
cell membrane | interferes
运输
dry ice
储存温度
−20°C
一般描述
化学结构：肽
应用
片球菌素的分子质量约为2,700至4,000 Da。它们是潜在的食品生物防腐剂，可用于控制食源性病原体和腐败变质。
生化/生理作用
片球菌素是一种IIa类细菌素，由 乳酸小球菌产生。它们是分子量约2700至4,000 Da的阳离子肽， 对病原菌如 单增李斯特菌、产气荚膜梭菌、粪肠球菌和 金黄色葡萄球菌表现出强烈活性。4 片球菌素的这种抗微生物活性是基于与胞质膜的相互作用，从而导致孔形成和细胞死亡。这些相互作用还会引起膜电位的变化，从而导致质子动力的损失和细胞内离子的流出，最终导致细胞死亡。 它们被证明可以抑制 单增李斯特菌。
其他说明
50 ug
保存于密闭容器内，置于干燥通风处。
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
监管及禁止进口产品
M J Pucci et al.
Applied and environmental microbiology, 54(10), 2349-2353 (1988-10-01)
The bacteriocin produced by Pediococcus acidilactici PAC 1.0, previously designated PA-1 bacteriocin, was found to be inhibitory and bactericidal for Listeria monocytogenes. A dried powder prepared from PAC 1.0 culture supernatant fortified with 10% milk powder was found to contain
A K Bhunia
Applied and environmental microbiology, 60(8), 2692-2696 (1994-08-01)
Monoclonal antibody (MAb) R2-AR against pediocin RS2 was developed. Mice were immunized for 12 weeks with pediocin RS2 conjugated to a polyacrylamide gel. Two hybridoma fusions yielded an MAb that in Western blots (immunoblots) reacted only with pediocins RS2 and
Pamela Oliveira de Souza de Azevedo et al.
Scientific reports, 10(1), 12291-12291 (2020-07-25)
Pediococcus pentosaceus LBM 18 has shown potential as producer of an antibacterial and antifungal bacteriocin-like inhibitory substance (BLIS). BLIS inhibited the growth of spoilage bacteria belonging to Lactobacillus, Enterococcus and Listeria genera with higher activity than Nisaplin used as control.
商品
由于细菌耐药性和新出现的传染病成为人类的潜在威胁，核糖体合成的抗菌肽已成为抗生素研究的一个有前途的重点领域。
Ribosomally synthesized antimicrobial peptides are a promising focus in antibiotic research amidst bacterial resistance and emerging infectious diseases.
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