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Merck
CN

L9756

(−)-四咪唑 盐酸盐

powder, ≥99% (GC)

别名:

L(−)- 2,3,5,6-四氢-6-苯基咪唑并[2,1-b]噻唑 盐酸盐, 左旋咪唑 盐酸盐, (S)-(−)-6-苯基-2,3,5,6-四氢咪唑并[2,1-b]噻唑 盐酸盐

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关于此项目

经验公式(希尔记法):
C11H12N2S · HCl
化学文摘社编号:
分子量:
240.75
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
240-654-6
MDL number:
Beilstein/REAXYS Number:
4358988
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产品名称

(−)-四咪唑 盐酸盐, ≥99% (GC)

InChI key

LAZPBGZRMVRFKY-HNCPQSOCSA-N

InChI

1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1

SMILES string

Cl.C1CN2C[C@@H](N=C2S1)c3ccccc3

biological source

synthetic (organic)

assay

≥99% (GC)

form

powder

mp

228-230 °C

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

antibiotic activity spectrum

parasites

mode of action

enzyme | inhibits

Quality Level

Application

适用于抑制各种哺乳动物碱性磷酸酶(例如,肝、肾、胎盘、骨和肿瘤)。
肠道碱性磷酸酶仅受到轻微抑制。
不适合兽医使用。

Biochem/physiol Actions

根据一些可控因素,同时显示免疫刺激和免疫抑制作用。治疗蛔虫病(钩虫感染)非常有效。可用于结肠直肠癌的化疗,可能是由于其刺激IL-1 产生和巨噬细胞的直接激活。

Other Notes

盐酸左旋咪唑可以 50mg/mL的浓度溶于水,产生澄清、无色的溶液。 在2-8℃ 下,溶液稳定保存约 1个月。

pictograms

Skull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Lei Guo et al.
Neuroscience bulletin, 35(2), 205-215 (2019-02-02)
The locus coeruleus (LC) has been studied in major depressive disorder (MDD) and bipolar disorder (BD). A major problem of immunocytochemical studies in the human LC is interference with the staining of the immunocytochemical end-product by the omnipresent natural brown
Lei Chang et al.
Bioorganic & medicinal chemistry letters, 21(8), 2297-2301 (2011-03-23)
Pathological calcifications induced by deposition of basic phosphate crystals or hydroxyapatite (HA) on soft tissues are a large family of diseases comprising of ankylosing spondylitis (AS), end-stage osteoarthritis (OA) and vascular calcification. High activity of tissue non-specific alkaline phosphatase (TNAP)
Lina Li et al.
Bioorganic & medicinal chemistry, 17(20), 7290-7300 (2009-09-29)
Presence of basic calcium phosphate in knee joints of osteoarthritis patients could be prevented by inhibiting tissue non-specific alkaline phosphatase (TNAP) activity. Levamisole or the L stereoisomer of tetramisole (a known TNAP inhibitor) has been used as a treatment for
Yongchan Lee et al.
Cell reports, 26(12), 3212-3220 (2019-03-21)
Metazoan cell death mechanisms are diverse and include numerous non-apoptotic programs. One program called entosis involves the invasion of live cells into their neighbors and is known to occur in cancers. Here, we identify a developmental function for entosis: to
Jonathan Graf
Current opinion in rheumatology, 25(1), 50-55 (2012-12-01)
Cocaine use is associated with several rheumatic syndromes. This review summarizes these clinical manifestations and highlights recent developments linked to levamisole-adulterated cocaine. Cocaine use has been linked to several distinctive syndromes that can be difficult to distinguish from idiopathic rheumatic

实验方案

Use this protocol to for the entire immunohistochemistry (IHC) procedure through staining and visualization of specific antigens in paraffin-embedded tissue sections.

本实验方案通过对石蜡包埋的组织切片中的特定抗原进行染色和成像,完成整个免疫组织化学(IHC)操作步骤。

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