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安全信息

I5159

Sigma-Aldrich

咪喹莫特

≥98% (HPLC), solid, caspase 3 activator

别名:

1-（2-甲基丙基）-1 H -咪唑 [4,5- c ] 喹啉-4-胺

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About This Item

经验公式（希尔记法）:
C14H16N4
CAS号:
99011-02-6
分子量:
240.30
MDL编号:
MFCD00866946
UNSPSC代码:
12352200
PubChem化学物质编号:
24724516
NACRES:
NA.77

产品名称

咪喹莫特, ≥98% (HPLC), solid

质量水平

100

方案

≥98% (HPLC)

表单

solid

溶解性

H2O: <2 mg/mL
DMSO: 4 mg/mL (warming to 60 °C for 15 minutes)

SMILES字符串

CC(C)Cn1cnc2c(N)nc3ccccc3c12

InChI

1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)

InChI key

DOUYETYNHWVLEO-UHFFFAOYSA-N

基因信息

human ... TLR7(51284)

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packaging

pkg of 5 ea

packaging

pkg of 5 ea

packaging

pkg of 5 ea

packaging

pkg of 2 ea

material

bevel tip stainless steel needle (point style 2)

material

bevel tip stainless steel needle (point style 2)

material

bevel tip stainless steel needle (point style 2)

material

blunt tip stainless steel needle (point style 3)

fitting

luer lock

fitting

luer lock

fitting

luer lock

fitting

luer lock

manufacturer/tradename

SGE 39811

manufacturer/tradename

SGE 39802

manufacturer/tradename

SGE 39807

manufacturer/tradename

SGE 39895

needle size

23 ga

needle size

23 ga

needle size

23 ga

needle size

22 ga

description

NLL-11.5/23

description

NLL-5/23

description

NLL-7/23

description

NLL-LC

一般描述

Imiquimod is a toll-like receptor (TLR)-7/8 agonist.[1]

应用

Imiquimod has been used as TLR7 agonist for TLR7 agonist enhancement studies.[2] It has also been used as an NLR family, pyrin domain containing 3 (NLRP3) stimulant to treat NLRP3-FL-Btn and FLAG-ASC-FL.[3]

生化/生理作用

咪喹莫特是半胱天冬酶 3 激活剂，可直接诱导半胱天冬酶 3 裂解为活性半胱天冬酶 3。咪喹莫特在体内 诱导基底细胞癌凋亡 。其抗肿瘤活性与诱导细胞凋亡有关。咪喹莫特具有抗血管生成、抗炎、抗病毒活性。咪喹莫特还可作为免疫应答调节剂，诱导多种细胞因子和趋化因子的分泌。
咪喹莫特是半胱天冬酶 3 激活剂，可直接诱导半胱天冬酶 3 裂解为活性半胱天冬酶 3。咪喹莫特在体内可诱导细胞凋亡 ，并作为一种免疫调节剂，具有抗病毒和抗炎特性。
Imiquimod helps to induce the innate cutaneous immunity and the cellular arm of the adaptive immune response.[1]

特点和优势

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301,H315,H319

危险分类

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

新产品
  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000436179
    0000436179
    0000338105
    0000241002
    0000241002

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    Topical imiquimod is and effective and safe drug for molluscum contagiosum in children
    Badavanis G, et al.
    Acta Dermatovenerologica Croatica, 25(2), 164-164 (2017)
    Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7
    Coleman L G, et al.
    Journal of Neuroinflammation, 14(1), 22-22 (2017)
    Tzu-Kai Lin et al.
    Environmental toxicology, 39(9), 4360-4371 (2024-05-18)
    The primary function of the skin is to form a mechanical, permeability, antimicrobial, and ultraviolet radiation barrier, which is essential for maintaining physiological homeostasis. Our previous studies demonstrated that cutaneous pigmentation could promote skin barrier function in addition to providing
    M H Roozeboom et al.
    The British journal of dermatology, 172(3), 739-745 (2014-07-30)
    A recent noninferiority randomized controlled trial (RCT) indicated that imiquimod can be considered as superior to methylaminolevulinate photodynamic therapy (MAL-PDT) in the treatment of superficial basal cell carcinoma (sBCC). Knowledge of treatment effectiveness in subgroups of patients is of great
    Jessica A Pane et al.
    PLoS pathogens, 10(3), e1003998-e1003998 (2014-03-29)
    It has been proposed that rotavirus infection promotes the progression of genetically-predisposed children to type 1 diabetes, a chronic autoimmune disease marked by infiltration of activated lymphocytes into pancreatic islets. Non-obese diabetic (NOD) mice provide a model for the human
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