D3168
Duramycin from Streptoverticillium cinnamoneus
≥90.0%
别名:
Duramycin, Lancovutide
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关于此项目
经验公式（希尔记法）:
C89H125N23O25S3
化学文摘社编号:
分子量:
2013.28
UNSPSC Code:
51102829
NACRES:
NA.85
MDL number:
产品名称
Duramycin from Streptoverticillium cinnamoneus, ≥90.0%
form
powder
assay
≥90.0%
solubility
0.1 M HCl: 10 mg/mL
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
mode of action
protein synthesis | interferes
storage temp.
2-8°C
Quality Level
Application
Duramycin is used to study chloride secretion by cardial, pancreatic and airway epithelial voltage-gated ion channels. It is used to study cystic fibrosis and as a novel phosphatidylethanolamine-binding molecular probe. It is used to stimulate sodium transport in cultured human colonic epithelia.
Biochem/physiol Actions
Duramycin is the smallest known polypeptide since it has only 19 amino acids. It has a defined 3-dimensional binding structure. Duramycin binds phosphatidylethanolamine (PtdE) at a 1:1 ratio with high affinity and exclusive specificity. It enhances chloride secretion in airway epithelium.
General description
Chemical structure: tetracycline
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Igor Oliynyk et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 118(12), 982-990 (2010-11-26)
The lantibiotic duramycin (Moli1901, Lancovutide) has been suggested as a drug of choice in the treatment for cystic fibrosis (CF). It has been proposed that duramycin may stimulate chloride secretion through Ca²(+) -activated Cl⁻ channels (CaCC). We investigated whether duramycin
M M Cloutier et al.
The American journal of physiology, 259(3 Pt 1), C450-C454 (1990-09-01)
The effect of duramycin, a polypeptide antibiotic, on Cl- transport in canine tracheal epithelium mounted in Ussing chambers was studied. Over a narrow concentration range, duramycin increased short-circuit current (Isc) and net Cl- secretion and had no effect on mannitol
Andrei Marconescu et al.
Biochimica et biophysica acta, 1778(10), 2217-2224 (2008-06-24)
The major anionic phospholipid, phosphatidylserine (PS), and the neutral phospholipid, phosphatidylethanolamine (PE), are largely confined to the inner leaflet of the plasma membrane bilayer in mammalian cells under normal conditions. This asymmetry is lost when cells undergo apoptosis, become activated
Kunihiko Iwamoto et al.
Biophysical journal, 93(5), 1608-1619 (2007-05-08)
Duramycin is a 19-amino-acid tetracyclic lantibiotic closely related to cinnamycin (Ro09-0198), which is known to bind phosphatidylethanolamine (PE). The lipid specificity of duramycin was not established. The present study indicates that both duramycin and cinnamycin exclusively bind to ethanolamine phospholipids
M M Cloutier et al.
Membrane biochemistry, 10(2), 107-118 (1993-04-01)
Duramycin increases short-circuit current (Isc) and net Cl- secretion in tracheal epithelium. We measured the intracellular free calcium ([Ca2+]i) response to duramycin using Indo-1 and bovine and canine tracheal cell suspensions, and the effect of an intracellular calcium chelator, BAPTA
商品
Ribosomally synthesized antimicrobial peptides are a promising focus in antibiotic research amidst bacterial resistance and emerging infectious diseases.
由于细菌耐药性和新出现的传染病成为人类的潜在威胁，核糖体合成的抗菌肽已成为抗生素研究的一个有前途的重点领域。
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