A6566
2-羟色胺
≥98% (TLC), solid
别名:
3-Amino-2-(4-chlorophenyl)-2-hydroxypropanesulfonic acid
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关于此项目
经验公式（希尔记法）:
C9H12ClNO4S
化学文摘社编号:
分子量:
265.71
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
2-羟色胺, ≥98% (TLC), solid
InChI
1S/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15)
SMILES string
NCC(O)(CS(O)(=O)=O)c1ccc(Cl)cc1
InChI key
WBSMZVIMANOCNX-UHFFFAOYSA-N
assay
≥98% (TLC)
form
solid
color
white
solubility
H2O: 1 mg/mL
0.1 M HCl: 1.2 mg/mL
methanol: 1.4 mg/mL
DMSO: 28 mg/mL
0.1 M NaOH: 9.5 mg/mL
Quality Level
Gene Information
human ... GABBR1(2550), GABBR2(9568)
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相关类别
Biochem/physiol Actions
Potent and selective antagonist at GABAB receptors.
signalword
Danger
hcodes
Hazard Classifications
Skin Corr. 1B
存储类别
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
K Obrietan et al.
Journal of neurophysiology, 82(1), 94-102 (1999-07-13)
In the mature nervous system excitatory neurotransmission mediated by glutamate is balanced by the inhibitory actions of GABA. However, during early development, GABA acting at the ligand-gated GABAA Cl- channel also exerts excitatory actions. This raises a question as to
D R Curtis et al.
Neuroscience letters, 92(1), 97-101 (1988-09-23)
When administered microelectrophoretically, a sulphonic acid derivative of baclofen, 3-amino-2-(4-chlorophenyl)-2-hydroxy-propylsulphonic acid, reversibly reduced the presynaptic reduction by (-)-baclofen of the monosynaptic excitation of spinal interneurones by impulses in low threshold primary afferent fibres of the cat as well as the
E N Backes et al.
Neurochemical research, 33(3), 459-467 (2007-10-19)
Recent evidence has suggested that compounds affecting GABAergic transmission may provide useful pharmacological tools for the treatment of cocaine addiction. Using a rat model of self-administration, the present study examined the effects of GABA agonists and antagonists injected directly into
Graciela N Balerio et al.
Pharmacological research, 46(3), 281-286 (2002-09-11)
The effect of baclofen, a GABA(B) agonist, has been studied in the hot plate test in mice, to analyze the possible involvement of the GABAergic system in baclofen analgesia. Baclofen (1-3 mg kg(-1) intraperitoneal (i.p.)) was found to elicit a
Satoshi Ikemoto
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 30(6), 1088-1095 (2005-02-04)
The supramammillary nucleus (SUM), a dorsal layer of the mammillary body, has recently been implicated in positive reinforcement. The present study examined whether GABA(A) receptors in the SUM or adjacent regions are involved in primary reinforcement using intracranial self-administration procedures.
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