抗体药物发现
从靶点发现到先导化合物优化,探索治疗性抗体发现工具。
单克隆抗体药物发现始于发现功能性治疗靶点,并评估其在目标疾病中的作用。随后,对该靶点涉及的分子机制进行特征鉴定。所有靶点都应具有可成药性并受潜在治疗药物调节。随着各种基因组工程和杂交瘤技术的出现,这些早期阶段工作已大幅简化,为生物治疗性抗体靶点和先导化合物发现提供了便利。
抢占先发优势
发现、筛选并验证与疾病密切相关的新靶点。药物发现流程的早期选择与药物发现计划的最终成败密切相关。确定最合适的可成药靶点是成功的关键。我们提供一整套精选全基因组、通路特异性和蛋白质家族靶向筛选工具,助力您的靶点发现。
- 用于靶点发现的功能基因组学筛选工具
- 用于靶点验证的体外工具
- 单克隆抗体生产
- 纯化方法
- 筛选候选单克隆抗体
- 先导化合物优化
- 临床前模型
- PK/PD和免疫原性
相关资源
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相关网络研讨会
可用功能基因组筛选技术概述、如何成功设计基因组筛选实验、混合CRISPR筛选以及新型药物靶点发现。
基因组编辑可行性概述、基因组探索、使用核酸酶缺陷型Cas9进行靶点识别以及生物标志物检测应用。
RNAi筛选与互补方法(如CRISPR-Cas9介导的基因组编辑)的交互为检测开发、筛选和验证开辟了新机遇。
相关类别
使用我们的CRISPR基因编辑工具敲除、敲入、敲低或过表达您的靶基因。
用于细胞系、原代细胞、类器官和高级细胞模型的细胞培养基。
实验室级、工艺级和工业级抗体色谱纯化。
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