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Key Documents

Safety Information

EHU031291

Sigma-Aldrich

MISSION® esiRNA

targeting human DKC1

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Select a Size

100 ML
¥211.05
500 ML
¥665.04
6 X 500 ML
¥2,434.10
24 X 500 ML
¥11,932.77

¥211.05

Available to ship on2025年4月14日Details

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Select a Size

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100 ML
¥211.05
500 ML
¥665.04
6 X 500 ML
¥2,434.10
24 X 500 ML
¥11,932.77

About This Item

UNSPSC Code:
41105324
NACRES:
NA.51

¥211.05

Available to ship on2025年4月14日Details

description

Powered by Eupheria Biotech

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

TGTGTGCACCTTGGTTTGTTATTGGGAGTTGGTGGTCAGATGCAGGAGCTTCGGAGGGTTCGTTCTGGAGTCATGAGTGAAAAGGACCACATGGTGACAATGCATGATGTGCTTGATGCTCAGTGGCTGTATGATAACCACAAGGATGAGAGTTACCTGCGGCGAGTTGTTTACCCTTTGGAAAAGCTGTTGACATCTCATAAACGGCTGGTTATGAAAGACAGTGCAGTAAATGCCATCTGCTATGGGGCCAAGATTATGCTTCCAGGTGTTCTTCGATATGAGGACGGCATTGAGGTCAATCAGGAGATTGTGGTTATCACCACCAAAGGAGAAGCAATCTGCATGGCTATTGCATTAATGACCACAGCGGTCATCTCTACCTGCGACCATGGTATAGTAGCCAAGATCAAGAGAGTGATCATGGAGAGAGACACTTACCCTCGGAAGTGGGGTTTAGGTCCAAAGGCAAGTCAGA

Ensembl | human accession no.

ENSG00000130826

NCBI accession no.

NM_001363

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... DKC1(1736) , DKC1(1736)

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This Item
PHR1419V900220100684
硝酸盐试剂 B suitable for microbiology

39441

硝酸盐试剂 B

对氨基苯磺酸 Pharmaceutical Secondary Standard; Certified Reference Material

PHR1419

对氨基苯磺酸

磺胺酸 Vetec™, reagent grade, 99%

V900220

磺胺酸

Sulfanilic acid for elemental analysis

100684

Sulfanilic acid

shelf life

limited shelf life, expiry date on the label

shelf life

-

shelf life

-

shelf life

-

composition

acetic acid (30%), 1000 mL

composition

-

composition

-

composition

-

technique(s)

microbe id | metabolite detection: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

application(s)

agriculture
clinical testing
environmental
food and beverages
pharmaceutical

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

suitability

Enterobacter spp.

suitability

-

suitability

-

suitability

-

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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    Khloud A Elsharawy et al.
    British journal of cancer, 123(10), 1543-1552 (2020-09-02)
    Hypertrophy of the nucleolus is a distinctive cytological feature of malignant cells and corresponds to aggressive behaviour. This study aimed to identify the key gene associated with nucleolar prominence (NP) in breast cancer (BC) and determine its prognostic significance. From
    Vahid Khoddami et al.
    Proceedings of the National Academy of Sciences of the United States of America, 116(14), 6784-6789 (2019-03-16)
    The breadth and importance of RNA modifications are growing rapidly as modified ribonucleotides can impact the sequence, structure, function, stability, and fate of RNAs and their interactions with other molecules. Therefore, knowing cellular RNA modifications at single-base resolution could provide
    Pingfu Hou et al.
    British journal of cancer, 122(5), 668-679 (2019-12-21)
    Dyskeratosis congenita 1 (DKC1) is dysregulated in several cancers. However, the expression and function of DKC1 in colorectal cancer (CRC) is rarely reported. Tissue microarrays (TAMs) including 411 cases of CRC tissues and corresponding paracancerous tissues were used to examine
    Meng Zhang et al.
    Oncology reports, 40(2), 968-978 (2018-06-15)
    DKC1, an X‑linked gene encoding dyskerin at Xq28, is a crucial component of the telomerase complex and is indispensable for normal telomere function and the post‑-transcriptional modification of precursor rRNA. It has been revealed to exert diverse biological functions and
    Nunzia Di Maio et al.
    FEBS open bio, 7(10), 1453-1468 (2017-10-06)
    Dyskerin is an essential, conserved, multifunctional protein found in the nucleolus, whose loss of function causes the rare genetic diseases X-linked dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome. To further investigate the wide range of dyskerin's biological roles, we set up stable
    View All Related Papers

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