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Merck
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BX-0400-30

Human Cortical GABAergic Neurons

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Human iPSC line, Fully differentiated, Healthy Male Control (no known neurological disorders), Cryopreserved

Synonym(s):

Inhibitory Neurons

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biological source

human (iPSC line)

form

frozen liquid

packaging

vial of 1 (contains ≥1 million cells)

technique(s)

cell culture | mammalian: suitable

storage temp.

-140 to -196°C

Related Categories

General description

Human iPSC-Derived Cortical GABAergic Neurons. Required supplements for the final cell differentiation and maturation (sold separately): BX-2400-100uL, BX-2020-100uL, BX-2040-100uL. Located in the basal forebrain, GABA neurons contain the neurotransmitter gamma-aminobutyric acid (GABA). GABA is an amino acid and the primary inhibitory neurotransmitter for the central nervous system, also known as the CNS. Because GABA reduces neuronal excitability and glutamate increases neuronal excitability, the balance between GABA and glutamate is important for proper neurologic function. Cortical GABAergic neurons can be used to study and understand diseases such as epilepsy, Alzheimer’s disease, and schizophrenia. Primary neurotransmitter released: GABA.

Application

Function: Cortical GABAergic Neurons exhibit pronounced electrophysiological activity after two weeks in culture, as demonstrated on multi-electrode array (MEA) recording systems.

Features and Benefits

Marker Expression: Fully differentiated Cortical GABAergic Neurons have high neuronal purity (>90%) and comprise predominantly inhibitory neurons. Labeling with the pan-neuronal marker MAP2 (green) and for GABA (red) highlight the purity of this neuronal product. Morphology: Cortical GABAergic Neurons exhibit substantial neurite outgrowth within a week in culture and are adherent. Calcein staining (green) demonstrates the characteristic cell shape and extension of processes of Cortical GABAergic Neurons in culture.

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Marina Bershteyn et al.
Cell stem cell, 30(10), 1331-1350 (2023-10-07)
Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy. One-third of patients have drug-refractory seizures and are left with suboptimal therapeutic options such as brain tissue-destructive surgery. Here, we report the development and characterization of a cell therapy

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