Skip to Content
Merck
CN

Develop the Next Generation of KRAS Inhibitors

Explore our organoid testing solutions

Test the efficacy of your compound(s) in a panel of 25 patient-derived organoids representing colorectal, lung, and pancreatic cancer. Our advanced screening capabilities include:

  • Direct measurement of cell viability with an image-based viability readout
  • High-throughput 3D assay format
  • Test any number of compounds, with no minimum number of models to enroll
  • High-dose quality with 10-point dose-response curves per compound
  • Inclusive of IC50 determination and heatmap generation

Accelerate your KRAS drug development with our comprehensive portfolio. Identify promising leads and understand compound mechanism of action to investigate and develop novel therapies. Book a consultation now!

Enroll Now

KRASmut Panel Features

  • Largest commercially available KRASmut PDO panel, with 25 models that represent pivotal KRAS mutants including G12A, G12D, G12V, G13D and many others
  • Rigorously characterized with readily available RNA or DNA sequencing data
  • Diverse models encompassing both primary and metastatic tumors, with the ability to test off-tumor toxicities with matched normal organoids

Applying our KRASmut PDO Screen

Our meticulously designed KRASmut panel was instrumental in developing a clinical candidate using organoid technology targeting head & neck cancer. Discover our proof-of-concept study and learn how PDOs can be used to accelerate your preclinical therapeutic development.

Related Products

Loading
Related Product Categories
Organoids
Organoids are in vitro models that closely replicate the complex physiology of native tissues while also being accessible, reproducible, and scalable like traditional culture methods. Choose colon organoids, lung organoid culture systems, and patient-derived organoids from our biobank.
Primary Cell Culture
Discover our collection of validated human primary cells from PromoCell® human primary cells, primary blood and immune cells from BioIVT, and more.
Hydrogels
Cells embedded in 3D hydrogels can polarize, differentiate and have functional attributes that more closely resemble physiological tissues. Choose naturally derived hydrogels or reconstitute a hydrogel from synthetic materials to develop predictive cellular models.
Millicell® Cell Culture Inserts & Plates
Enhance cell culture with Millicell® inserts, plates, chamber slides, flasks. Achieve biologically relevant growth, choose hanging or standing inserts.
Classical Media & Buffers
Choose from a range of optimized cell culture media formulations, including DMEM, RPMI-1640, and serum-free options for diverse cellular needs.
Live Cell Imaging Reagents
Nontoxic reagents enable live cell imaging for real-time visualization of cellular events, ensuring cell protection during experimentation.
Animal Component Free Cell Culture Reagents
Achieve consistent stem cell, inflammation, and cancer research results with our animal component-free cell culture solutions.
Supplements for Cell Culture
Cell culture supplements enable the customization of media with defined characteristics to support specific applications and serum-free culture needs. Our culture-grade supplements include ITS formulations, amino acids, vitamins, antibiotics, and reagents qualified for hybridoma and insect cell culture.
Related Applications
Pharmacology & Drug Discovery Research
Pharmacology & Drug Discovery Research
3D Cell Culture
Explore scaffold and scaffold-free methods for three-dimensional (3D) cell culture, including organoids and spheroids.
Primary Cell Culture Techniques
Cultivate mammalian primary cells for ADME/Tox screening, maintaining physiological relevance for accurate results.
Cell Culture Troubleshooting
Expert tips for correcting common problems with cell culture including bacterial and fungal contamination, debris in culture media, cell detachment or clumping, slow growth, and low viability.